
Appetite regulation
Semaglutide activates GLP-1 receptors involved in hunger and satiety, helping reduce appetite and caloric intake.
$299.00 $200.00/mo, 2 month supply 1 vial
A once-weekly prescription injection combining semaglutide + B12 to support appetite control, weight management, glucose regulation, and metabolic health.

May support appetite control: Targets GLP-1 pathways involved in hunger and satiety.

May support weight management: Helps reduce appetite and caloric intake as part of a clinician-guided weight-management program.

May support glucose regulation: Helps regulate glucose-dependent insulin secretion and glucagon activity.

May support metabolic health: May improve multiple metabolic parameters alongside appropriate nutrition, activity, and clinical care.
Semaglutide can cause gastrointestinal and other adverse effects and is not appropriate for every patient.
Semaglutide carries a boxed warning regarding the risk of thyroid C-cell tumors observed in animal studies.
Semaglutide is contraindicated in patients with:
Additional clinical considerations may include:
Semaglutide delays gastric emptying and may affect the absorption of certain oral medications. Patients should review their complete medical history, medications, and supplements with their prescribing clinician before treatment.
Because compounded formulations may differ from FDA-approved semaglutide products, patients should follow the exact concentration and dosing instructions provided with their prescription.
Commonly reported side effects may include:
Gastrointestinal symptoms may be more noticeable when beginning treatment or following an increase in dose.
No. Compounded Semaglutide + B12 is not FDA-approved. FDA-approved medications containing semaglutide are available separately, but compounded semaglutide + methylcobalamin is distinct from FDA-approved branded products.
Semaglutide activates GLP-1 receptors involved in appetite and satiety. This can reduce hunger and caloric intake while supporting glucose regulation, which may contribute to weight reduction over time.
Methylcobalamin is an active form of vitamin B12 involved in cellular energy metabolism, red blood cell formation, DNA synthesis, methylation, and normal neurological function.
Vitamin B12 supports the body’s normal energy-producing processes by helping cells metabolize nutrients. It does not act as a stimulant.
Methylcobalamin is an active form of vitamin B12 that can participate directly in B12-dependent biochemical pathways, including the conversion of homocysteine to methionine.
Semaglutide + B12 is administered once weekly according to your prescribed dosing protocol. Increase the dose only when appropriate and as directed by your prescribing clinician.
Semaglutide is administered subcutaneously. Common injection areas include the abdomen, thigh, and upper arm. Follow the administration instructions provided by your clinician and pharmacy.
Appetite and glucose-related effects may occur relatively early in treatment, while changes in body weight generally occur progressively over time. Individual response varies.
No. Semaglutide is a GLP-1 receptor agonist, while tirzepatide activates both GIP and GLP-1 receptors. Although both may be used in weight-management and metabolic-health settings, they are different medications.
A compounded semaglutide prescription may be provided through telehealth when a licensed clinician determines that treatment is medically appropriate and applicable prescribing and compounding requirements are satisfied.
Not necessarily. Follow the dosing protocol provided by your prescribing clinician and increase the dose only if needed and directed to do so.
Semaglutide + B12 is a compounded prescription medication combining semaglutide, a GLP-1 receptor agonist, with methylcobalamin, an active form of vitamin B12.
Semaglutide acts on GLP-1 receptors involved in appetite, satiety, glucose regulation, and metabolic signaling. By helping reduce appetite and caloric intake while supporting glucose regulation, semaglutide may be incorporated into clinician-directed weight-management and metabolic-health programs.
Methylcobalamin provides vitamin B12, an essential nutrient involved in normal red blood cell formation, neurological function, DNA synthesis, and cellular energy metabolism.
This compounded formulation is not FDA-approved. FDA-approved semaglutide products are available separately under branded formulations and indications.
All dosing should follow the instructions provided by the prescribing clinician.
Semaglutide mimics the activity of GLP-1 (glucagon-like peptide-1), a naturally occurring incretin hormone involved in appetite, digestion, insulin secretion, and glucose regulation

Semaglutide activates GLP-1 receptors involved in hunger and satiety, helping reduce appetite and caloric intake.

GLP-1 signaling promotes feelings of fullness, which can support reduced food intake.

Semaglutide helps stimulate insulin secretion when blood glucose is elevated, supporting glucose regulation.

Semaglutide can decrease inappropriate glucagon secretion, helping reduce excess glucose production by the liver.
Semaglutide belongs to a class of medications known as GLP-1 receptor agonists. FDA-approved semaglutide products are indicated for specific uses, including type 2 diabetes and chronic weight management in eligible patients. Compounded Semaglutide + B12 is a separate formulation and is not itself FDA-approved.
Treatment eligibility is determined through an individualized medical evaluation.
All dosing should follow the instructions provided by the prescribing clinician.
Semaglutide + B12 Injectable combines semaglutide, a GLP-1 receptor agonist, with vitamin B12 to target pathways involved in glucose regulation, appetite signaling, and cellular metabolism. Semaglutide may enhance glucose-dependent insulin secretion, modulate glucagon signaling, slow gastric emptying, and influence appetite and satiety pathways within the central nervous system. Vitamin B12 serves as an essential cofactor involved in red blood cell formation, DNA synthesis, neurologic function, and cellular energy metabolism.


May support appetite control: Targets GLP-1 pathways involved in hunger and satiety.

May support weight management: Helps reduce appetite and caloric intake as part of a clinician-guided weight-management program.

May support glucose regulation: Helps regulate glucose-dependent insulin secretion and glucagon activity.

May support metabolic health: May improve multiple metabolic parameters alongside appropriate nutrition, activity, and clinical care.
Concentration: 2.5mg/2mg per mL in 2mL (5mg/4mg per vial)
Administer once weekly following the conservative dosing protocol. Increase the dose only if needed. Supplies included.
*$200.00/mo; includes your prescription, supplies, shipping, and product support. 2 month supply per vial (varies with titration schedule)*
Prescription products require a medical consultation with a licensed provider, who will determine whether treatment is clinically appropriate. Please refer to each product page for important safety information. Any benefits described on Celia-rx.com are based on third-party research and published studies.
These statements have not been evaluated by the Food and Drug Administration. Products and services offered by CeliaRx are not intended to diagnose, treat, cure, or prevent any disease.
This medication is prescribed only when deemed medically appropriate following a clinician’s review. It is not prescribed for performance enhancement purposes. All prescriptions require consultation with a licensed provider (via secure telehealth). If the provider determines the medication is not appropriate for you, you will receive a full refund.
*All products shipped from our pharmacy partner will look different upon arrival. CeliaRx products are only labeled to see brand and product information.
* All products are compounded by Partell Pharmacy.
Book a consult with a Celia specialist to determine your ideal product protocol.
Book ConsultationWelcome to Celia. We are excited to work with you.
We use cookies to improve your browsing experience, analyze website traffic, and personalize content. You can accept or decline non-essential cookies at any time. For more information, please read our Cookie Policy
Required for the website to function. Cannot be disabled.
Help us understand how visitors interact with the website.
Used to deliver relevant advertisements and track campaigns.
Remember your settings and preferences for a better experience.
No preference cookies are used on this site.